Search results for " energy crisis"
showing 4 items of 4 documents
Smart-City Citizen Engagement: The Answer to Energy Savings in an Economic Crisis?
2022
As the populations of cities grow, it is obvious that they need more and more resources. Energy is currently one of the most desirable resources due to the economic and energy crisis, but it needs to be used in a sustainable manner. There are cities that achieve smart city (SC) status that provide smart policies towards sustainable development. The aim of the present paper is to determine whether citizen engagement in SC can contribute to reduced energy consumption in the current economic crisis. The paper presents an original survey intended to collect primary data and a study conducted based exclusively on qualitative methods. The results concern a broad and multifaceted review of literat…
The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence
2020
Alzheimer’s disease (AD) is a fatal form of dementia of unknown etiology. Although amyloid plaque accumulation in the brain has been the subject of intensive research in disease pathogenesis and anti-amyloid drug development; the continued failures of the clinical trials suggest that amyloids are not a key cause of AD and new approaches to AD investigation and treatment are needed. We propose a new hypothesis of AD development based on metabolic abnormalities in circulating red blood cells (RBCs) that slow down oxygen release from RBCs into brain tissue which in turn leads to hypoxia-induced brain energy crisis; loss of neurons; and progressive atrophy preceding cognitive dysfunction. This …
The rediscovery of nature: the lost innocence of the digital world
2022
L’impatto della nostra impronta ecologica legata al tasso di crescita incontrollato della tecnologia digitale sta portando ad un aggravamento degli squilibri ambientali esistenti. Il digitale e i new media che fino a ieri ci apparivano una terra promessa dell’emancipazione umana, oggi rilevano enormi effetti inquinanti sulla biosfera che devono essere obbligatoriamente evidenziati. Nel contributo si intende sottoporre a indagine le cause della “perduta innocenza” del mondo digitale anche attraverso una ricostruzione analitica sui fenomeni che sino a poco tempo fa venivano percepiti come veicoli immateriali, assolutamente non invasivi per l’ambiente e dalle straordinarie potenzialità di prog…
A Look into Liver Mitochondrial Dysfunction as a Hallmark in Progression of Brain Energy Crisis and Development of Neurologic Symptoms in Hepatic Enc…
2020
Background: The relationship between liver disease and neuropathology in hepatic encephalopathy is well known, but the genesis of encephalopathy in liver failure is yet to be elucidated. Conceptually, the main cause of hepatic encephalopathy is the accumulation of brain ammonia due to impaired liver detoxification function or occurrence of portosystemic shunt. Yet, as well as taking up toxic ammonia, the liver also produces vital metabolites that ensure normal cerebral function. Given this, for insight into how perturbations in the metabolic capacity of the liver may be related to brain pathology, it is crucial to understand the extent of ammonia-related changes in the hepatic metabolism th…